February 8, 2023
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Obesity Raises a Man’s Odds for Fatal Prostate Cancer – Consumer Health News


Thursday, May 5, 2022 (Health Day News) – Men with a wide waist are more likely to die of prostate cancer.

In particular, every 4-inch increase in belly fat increases a man’s risk of dying from prostate cancer by 7%, new research suggests.

“Our results will encourage men to maintain a healthy weight,” said Dr. Aurora Perez-Carnago, co-author of the study. University Of Oxford Inside England. Exactly why overweight men are more likely to die from prostate cancer is still not fully understood.

“It is possible that some molecular disturbances in obese men may be the cause of this increased risk, but it is also possible that obese men may be diagnosed later than normal weight men, and therefore tumors may be diagnosed at a more advanced stage.” Perez-Carnago says.

More research is needed to determine whether weight loss in obese men reduces the risk of dying from cancer, he said.

For the study, researchers reviewed data from 2.5 million men from 19 published studies and a new analysis of more than 200,000 men who were part of the UK’s biobank.

At the beginning of the study, none of the men had prostate cancer. Weight was assessed by body mass index (an estimate of fat based on BMI, weight and height), waist circumference, waist-to-hip ratio, and / or body fat percentage.

All of these measures have increased the risk of dying from prostate cancer, and every five-point increase in BMI has increased the risk of dying from prostate cancer by 10%, the study found.

Furthermore, a 5% increase in total body fat percentage increased the risk of death from prostate cancer by 3%, and every 0.05 increase in waist-to-hip ratio increased the risk of death from prostate cancer by 6%, the researchers found.

The results were presented at the European Congress on Obesity this week MaastrichtThe The NetherlandsAnd published online on 5 May BMC Medicine.

According to experts who are not involved in the new study, these results are another reason for overweight or obese men to lose weight.

“The meta-analysis presented in this publication is consistent with other possible analyzes that support obesity and central adiposity as a risk factor for prostate cancer and death,” said Dr. Andrew Lache, a medical oncologist at the Memorial Sloan Kettering Cancer Center in Montwell. , NJ

Current research suggests that hormonal and inflammatory changes may contribute to the development of prostate cancer, Lassetti said.

“Advanced estradiol-to-testosterone ratio, a hormone change observed in men’s waist circumference, is thought to lower prostate-specific antigen (PSA) levels, which may delay the detection of prostate cancer, leading to a more advanced diagnosis. . ” He added.

High blood levels of PSA may signal the presence of prostate cancer.

“This is a well-conducted study that reinforces what I tell my patients: If you are overweight or obese, try to lose weight,” agrees Dr. Stephen Friedland. He runs the Center for Integrated Research in Cancer and Lifestyle at Cedars-Sinai. Angels. “It’s also important to talk to your doctor about when to screen for prostate cancer so you can catch it as soon as it’s in its most curable stage,” Friedland said.

More info

Learn how to prevent prostate cancer in the American Cancer Society.

Sources: Aurora Perez-Carnago, PhD, Nutritional Epidemiologist, University of Oxford, England; Andrew Lachetti, MD, Medical Oncologist, Memorial Sloan Kettering Cancer Center, Montvale, NJ; Stephen Friedland, MD, Director, Center for Integrated Research in Cancer and Lifestyle, Cedars-Sinai, Los Angeles; European Congress on Obesity, Maastricht, Netherlands, May 4 to 7 2022; BMC MedicineMay 5, 2022, online

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