Thursday, May 5, 2022 (HealthDay News) – In the Pediatric Intensive Care Unit (PICU), multidisciplinary diagnostic stewardship intervention may reduce blood culture and antibiotic use, according to a study published online May 2. Clothing pediatrics.
Charlotte J. Woods-Hill, MD, and colleagues from Children's Hospital, Philadelphia, examined a 14-site multidisciplinary PICU blood culture association that examined culture rate, antibiotic use, and a potential quality improvement (QI) study. The QI program focuses on blood culture practice at PICU.
The researchers found that pre-requisite blood culture rates per 14 patients-day / month across 14 PICUs were 149.4 and 100.5 per 1,000 patient-days / month post-implementation, representing a relative reduction of 33 percent. Broad-spectrum antibiotic use rates decreased from 506 to 440 days per 1,000 patient-days / month (a relative decrease of 13 percent) compared to the period before and after implementation. Broad-spectrum antibiotic initiation rates decreased from 58.1 to 53.6 initiations / 1,000 patient-days / month, a relative decrease of 8 percent. Also, there was a relative reduction of 36 percent in the rate of transfusion of central line-related blood flow, from 1.8 to 1.1 per 1,000 central venous lines per day / month. Before and after implementation, mortality, length of stay, recurrence, sepsis and severe sepsis / septic shock were similar.
“Our research confirms that diagnostic stewardship is a promising strategy for increasing antimicrobial stewardship programs and reducing overuse of antibiotics,” the authors wrote.
Several authors have revealed the financial relationship with the pharmaceutical industry.
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